Plexi pros: light weight, better thermal insulation, flexes so it will not shatter, about 20% more transparent than glass, cheaper on big tanks easier to customize
Plexi cons: cost alot more on small tanks, scratches easier but you can fix scratches
Glass Pros: Cheap on shallow tanks, easily found, harder to scratch
Glass Cons: Weighs about 2 times more than acrylic, cannot fix scratches, harder to customize, brittle, silicone seams eventually need re-done